Research topic: Organic and biological chemistry

How to apply: uom.link/PGR-Apply-2425

UK students

This 4 -year doctorate is open to home applicants (UK). A successful candidate will receive an annual tax -exempt at a Ukraine rate (20,780 pounds for 2025/26, according to the annual height), and tuition fees will be paid. We expect the salary to increase every year. The start date is October 2026.

We recommend that you make the progress early as the advertisement will be removed as soon as the position is fill.

The ecclesiastical nucleosids for building blocks for the vital particles of life. They are integrated components of algnocyotides (DNA and RNA) that encrypt the proteins required to control biological processes. Nucleiosids are also present within the auxiliary factors of the enzyme (NAD+/H), as the sources of cellular energy (ATP) and as secondary signaling particles (periodic Dincoliotides). Synthetic nucleosids, nucleotides, and cystiotides are a successful strategic strategy to develop treatments that target various biological processes. These include the symmetrical versions of DNA, copies, translation and cell signal. For embodiment, nucleuside analogues have a brilliant history of therapeutic intervention strategies, especially against viruses (for example, Entecavir, Sofosbuvir) and cancer (for example, Clofarabin, Furodesin) (1,2). Signal molecules consist of two components of nucleotides associated with phosphodester, which control many operations in both the mediator and real nucleus memory. It stimulates the stimulus of the interferon genes (STING) to devise an immune response and is currently evaluated as possible cancer treatments. (5) On a large scale, nucleuside analogues and nucleotides are targeted to exercise their therapeutic effect. In comparison, the treatments from the algnocyotide (or DNA) are usually targeted by flexible to cancel the production of proteins associated with diseases. (6) Alleginokoliottide treatments are an emerging drug method that consists of short or modified short or modified nuclear sequences; These include anti -infants (ASOS), Sirnas, Microrna (Mirnas), Aptamers, and DNAZYMES. (7) Also noticeable from recent times is the use of the Algonoklotide sequence (MRNA) in the development of a SARS 2 vaccine.
To meet the increasing demand for the next generation, the small molecule and the remedies based on RNA, new nucleuside analogy. This is intended by the need to develop more efficient, sustainable and cost -effective industrial methods to produce them. Based on the previous work of the group in this field (Millerressechgroup.co.uk), (8-14This doctorate will include the chemical design and synthesis of new nucleuside and nucleotides to enable its evaluation in related biological systems. You will receive training in organic synthesis, carbohydrate chemistry, chemical synthesis, and molecular microbiology, all directed towards designing and developing roads to the goals of new nucleoside/nucleotides. Convertible skills such as reporting orally and in writing, time management, and managing projects will be developed and managed.

Applicants must have, or expect to achieve, at least, at least 2.1 degrees or master’s degree (or international equivalent) in the field of relevant science or engineering.

To apply, please contact the supervisors; Professor Gavin Miller – Gavin.miller@manchester.ac.uk And Dr. Louvlock – Sarah.loveckk@manchester.ac.uk. Please include details of your current level of study, academic background and any related experience and insert a paragraph about your motives for studying this doctorate project.