We invite requests from creative and enthusiastic individuals to join Professor Sir Shankar Palacarian for a PhD for 4 years, working on a multidisciplinary project that takes advantage of both chemistry and biology to explore the basic mechanisms of the genome function (http://www.Balasubramanian.co.uk).

Our projects include the development and use of advanced techniques in chemical biology, vital molecular physics and structural biology, especially genome science. Students will contribute to one or more basic research areas below:

Our main interest is on the structure and function of the secondary acid structures (and RNA) called G-QUADRUPEXES (G4S). Studies indicate that the G4S is important to control copies, translation and other major biological mechanisms. We aim to clarify their role, their interactions with proteins and explore intervention strategies based on small cancer molecules (for example see genome biology, 2025, 25, 155; nature chemistry, 2025, 17, 875

At the last work, we have developed techniques to draw a map where small molecules are associated with DNA and RNA, and to identify proteins associated with their connection sites with the aim of understanding therapeutic mechanisms (for example, See Nature Biotechnology 2023, 41 1265). We expand this work to create ways to characterize small molecular reactions with DNA, RNA and associated proteins. We are taking advantage of the results we have reached from these methods to design small dual -functional particles targeting genetic proteins and associated chrome.

This position will be primarily at the Balasubramanian Laboratory in the Yusuf Hamied section of chemistry and will include cooperative interactions with the group’s sister’s laboratory at the Cruk Cambridge Institute.

The student will be very excited, able to think independent and have excellent communication skills with the ability to work cooperatively. Ideally, the filter will have a strong background in biochemistry/biochemistry and/or molecular biology. A good knowledge of the chemical/chemical/chemical biology of nucleic acids is very desirable.

The course begins in October 2026 and provides a scholarship and fees for the UK rate. However, we can support distinguished foreign students in their request for a suitable grant.

To apply, please send an email to a coverage letter, a biography, detailed academic texts and contact details for two academic rulers directly to: Joe Lockhart, Director of Group Sciences in October (BalasubramanRUITMMENT@CH.CAM.AC.UK), Including “PhD: October 2026” in the subject line.

You must explain your coverage letter why you want to look at the medicine and prescribe the relevant traits and experience that you have to obtain a PhD. Please also mention how you learned from this grant.

For the round -related inquiries, please contact Jo on BalasubramanRUITMMENT@CH.CAM.AC.UK.

The interviews will be held on Tuesday 25 November 2025.

Please quote the MA47419 reference on your request and in any correspondence on this vacancies.

The university supports the activity of equality, diversity and inclusion and encourages requests from all sections of society.