location: Old Right of Way, Headington, Oxford, OX3 7LF

salary: Standard Grade 8: £49,119 – £58,265 with discretionary range up to £63,489 per annum (pro rata). This includes the Oxford University Pension Weight of £1,730 per annum (pro rata)

Help us advance a landmark, multi-country trial to find safe and affordable treatments for dengue. We are seeking an experienced Clinical Trials Director to support DEN-HOST, a large randomized phase III adaptive trial evaluating treatments for patients hospitalized with moderate or severe dengue. This post will be based at the Big Data Institute, Li Ka Shing Center for Health and Information Discovery, Old Road Campus, Headington, Oxford, OX3 7LF.

The trial aims to identify safe and affordable treatments that prevent disease progression in high-risk patients and improve outcomes for those with severe disease, thus reducing the burden on health systems in dengue endemic areas. DEN-HOST will initially test three host-directed therapies. The trial aims to recruit up to 8,000 patients across 25 sites in Peru, Colombia, Brazil, Bangladesh, Indonesia, Malaysia, Cambodia, Thailand, Nepal and Vietnam, over 5 years. It will build on existing networks including RECOVERY, ISARIC, PREPARE and OUCRU.

You will play a key role in setting up the trials, including establishing Regional Coordinating Centers (RCCs), establishing governance and operational frameworks, as well as leading the delivery and oversight of the ongoing trials once recruitment commences. This will include serving as the primary operational contact for RCC leaders, monitoring registration and trial conduct, coordinating protocol amendments, ensuring governance and regulatory compliance, and overseeing trial documentation. You will also provide leadership within the CCO, including direct management of the Clinical Trials Assistant, and help ensure effective and collaborative working practices across all partners.

It is essential that you have a university degree in biomedicine or a related subject, or any other relevant qualification, demonstrated experience in clinical research and significant experience in setting up and delivering international clinical trials. Strong knowledge of ethics applications, sponsor approvals, clinical trial agreements, due diligence, risk and governance frameworks is also essential, along with experience managing multiple partner budgets and reporting. You will also need excellent communication skills, the ability to work collaboratively across multi-disciplinary and multi-country teams, and previous direct management experience.

Applications for this vacancy must be submitted online and you will need to upload a supporting statement and CV. Your supporting statement should explain how you meet each of the selection criteria for the job using examples of your skills and experience. Please limit your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

This full-time position is offered on a fixed-term contract until 30 September 2027 and is funded by Wellcome. Interviews will be conducted the week of November 17, 2025.

Only applications received before 12 noon on Wednesday 5 November 2025 will be considered. Please quote 182438 in all correspondence.