background: The impact of diet on mental health and brain performance is a topic of increasing focus and concern: diets high in saturated fat have been associated with a higher risk of cognitive decline later in life, while healthy diets rich in plant polyphenols are associated with a lower risk of dementia. In addition, the increasing prevalence of stress in our societies also contributes to impaired brain function: for example, chronic stress alters functional connectivity, impairs attention, and increases the risk of cardiovascular disease. Importantly, unhealthy/healthy food choices may exacerbate or protect vascular and brain function from the effects of mental stress.

We have shown that flavonoid-rich foods can prevent the negative effects of stress on vascular function when consumed in isolation and in the context of a high-fat meal. Ingestion of flavonoids prior to physiological stress also results in higher and faster levels of cerebral oxygenation in the prefrontal cortex and better cognitive performance in young, healthy individuals. As such, flavonoid-rich goods can be used as a strategy to reduce the impact of stress on brain and mental health, as well as cardiovascular health.

Objectives: In this project, our main objectives are to investigate whether single and habitual intake of polyphenols with the diet improves brain oxygenation and arterial function in the context of stress, leading to better cognitive performance and improved mood in healthy middle-aged adults. These data will determine whether dietary polyphenols are effective in reducing the impact of stress on mood and cognitive function, by modulating basic physiological responses to stress. We will also identify individuals who may benefit most from incorporating polyphenols into their diet during periods of stress.

indication: Stress is widespread in society and is a risk factor for heart disease, obesity, and poor mental health. This work will have implications for understanding the health impact of polyphenol intake to build physiological resilience against and/or rescue from the negative effects of stress. Ultimately, this may impact overall diet and long-term health, and may shape future dietary guidelines on diet around stress.

Opportunities/training for the student:

This is a multidisciplinary project that will provide training in a number of different areas such as:

• Nutrition: Conducting randomized controlled human dietary intervention trials
• Physiology: Training in i) ultrasound methods to evaluate endothelial function and blood flow in human arteries; b) Near-infrared spectroscopy to evaluate cerebral vascular function
• Psychology: Training in assessing human cognitive performance/mood
• Exercise Physiology: Assessing Cardiorespiratory Fitness (VO2max Tests)

The successful candidate will be part of the vibrant PhD community in the School of Sport, Exercise and Rehabilitation Sciences. They will be trained by senior researchers within our research group. The student will have the opportunity to attend a scientific conference and be part of public engagement activities on nutrition and health.

Person specifications:

required:
First degree or 2:1 in relevant subject area

The best:
1) Master in relevant subject area
2) Preference will be given to candidates with experience in a research setting, especially conducting human studies

Informal inquiries are frequently encouraged and should be directed to Dr. Catarina Rindero (c.rendeiro@bham.ac.uk)

To apply, click the “Apply” button above.

Apply to the 0355 PhD Sport & Practice FT program and choose “Dr Catarina Rendeiro” as lead supervisor. Please provide:
• the biography
• Names and addresses of two referees
• Cover letter