Funding amount: It will cover the financing tuition fees For UK students (at home rate), salary in Ukraine averageAnd the budget of consumer materials.

This is PhD students for 3.5 years funded by the College of Life Sciences, starting from 1^street October 2026 under the supervision of Dr. Lydia Vasiliva, College of Life Sciences.

Project Description:

Modern technological developments have revealed a large number of Non -encrypted RNA (NCs), which is produced from real -core genotations, as well as protein coding. Mutations in the unencrypted areas of the genome and the changing expression of NCRNAS supports a number of diseases including cancer. However, very little is known about the mechanisms involved in the production of NCRNAS that prevents us from understanding its role in health and disease. Our previous work discovers that unlike MRNAS, NC texts depend on unprecedented and understandable mechanisms that control Polyrase II (POL II) copies. As a result, NCRNAS non -polyidlins is targeted by the mechanism of degradation of cellular DNA, RNA Exosome.

The PhD project aims to fill the main gaps in our understanding of the copying mechanisms participating in the creation and maturity of NCRNA. This will be achieved through goals 1-3. The PhD student will define and distinguish the factors associated with the production of NCRNA chemically (target 1), investigate how to recruit it in Pol II during copies and how to control the vital generation of NCRNA and contribute to regulating genetic expression using modern genetic methods (AIM 2 and 3). The laboratory uses many models systems including yeast, C. Elegans And mammal cells.

References:

www.vasilievalb.com

Plunsiles.sussex.ac.uk/p634884-Lidia-Vasiliva

www.bioch.oc.ac.uk/research/vasilieva

1. Vaselvieh, l. (2025) The role of the DSIF SPT5 worker in coordinating the Pol II process and the XRN22 to finish the copies. Nature community 16 (1): 10. Doi: 10.1038/S41467-024-55063-7.

2. Birot, A., Kus, K., Priest, E. Vaselvieh, l. , Kilchert, C. (2021) protein associated with RNA MUB1 and RNA Exosome nuclear work for well environmental stress response. SC life. alliance5, 2: e202101111.

Civilization and how to apply:

Please send an official request using the online admission portal (via ”Progress“The above button) attach the CV, the texts of certificates and certificates, and academic two. The research suggestion is not required. Instead, please download a personal statement that describes the areas of interest, skills and previous experiences, motivation for doctoral research, future goals, and why you advance to this project.

In the application system, select the study program – Ph.D. Ph.D.. Please specify “financing obtained” and mention the name of the supervisor as necessary.

Candidates should have or expect a university degree at least 2: 1. Master’s degree is useful. It should be qualified in biochemistry or the field of relevant topic. Candidates who do not require English for the first language IELTS 6.5 total or equivalent – English language requirements

For inquiries about the application, please send an email to Emma Shorley: lifesci-rec@sussex.ac.uk

Applicants are encouraged to conduct unofficial inquiries about the project to Lidia Vasilieva Lvvasilieva@sussex.ac.uk